Praziquantel for Dogs and Cats

Dosage Forms Available:

  • Tablets
  • Capsules
  • Oral Liquid
  • Chew Treats
  • Injection

 

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Praziquantel antiparasitic dewormer for treating a variety of parasite infections, most commonly tapeworms. Praziquantel is also commonly used in combination with other antiparasitic medications.

 

What is Praziquantel?

Praziquantel is a veterinary medication. Praziquantel is an anthelmintic agent with activity against a broad spectrum of trematodes and cestodes that is used predominantly in the therapy of schistosomiasis, liver flukes, and cysticercosis.

Praziquantel is 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline-4-one. It is a white to nearly white crystalline powder of bitter taste, melting at 136-140°C with decomposition. It is stable under normal conditions and it is practically insoluble in water, sparingly soluble in ethanol and soluble in organic solvents like chloroform and dimethylsulfoxide.  Praziquantel possesses an asymmetric center in position 11b (asterisk). The commercial preparation is a racemate composed of equal parts of “levo” R(-) and “dextro” S(+) isomers. Only the (-)-enantiomer is endowed with antischistosomal activity.

 

What is Praziquantel Used for In Dogs?

Praziquantel is primarily used in dogs and puppies as a tapeworm dewormer ,Dipylidium caninum and Taenia pisiformis.

 

 Praziquantel Side Effects in Dogs

Side effects of Praziquantel for dogs are uncommon. 

 

Less Common Side Effects

  • Lethargy
  • Diarrhea
  • Drooling
  • Vomiting
  • Loss of Appetite

If you notice any of these Praziquantel side effects in dogs, contact your veterinarian right away. In the event of an allergic reaction, seek immediate medical attention for your animal.

 

Praziquantel Precautions

Praziquantel for dogs may not be the best treatment for all veterinary patients.

 

Who Should Not Use Praziquantel

Animals allergic to it, puppies less than 3 weeks old, or kittens less than 6 weeks old.

 

Are There Any Drug Interactions With Praziquantel?

Praziquantel

Albendazole

Increased plasma concentration of active metabolite of albendazole

Praziquantel

Carbamazepine

Plasma-praziquantel concentration reduced

Praziquantel

Chloroquine

Plasma-praziquantel concentration possibly reduced

Praziquantel

Dexamethasone

Plasma-praziquantel concentration reduced

Praziquantel

Phenytoin

Plasma-praziquantel concentration reduced

 

Storage

Praziquantel tablets are best stored in a cool dry place. Tablets should be in a tightly sealed container and kept away from direct sunlight.

Liquid praziquantel should also be stored at room temperature. Shake well before administering the dosage.

Medications should not be ingested by humans. In homes with children, a childproof container is recommended. If a human accidentally swallows this medication, call your doctor right away.

Instructions

Give this medication exactly as directed by your veterinarian. If you do not understand these directions ask the veterinarian to explain them to you. 

Unless otherwise directed by your veterinarian, The PO (5 mg/kg), SC (5.8 mg/kg), or spot-on (cats, 12 mg/kg) administration of praziquantel in dogs and cats is 100% effective against Dipylidium caninum, Taenia spp, and Echinococcus spp (both adult and immature forms). Follow your veterinarian’s instructions as they may differ from these recommendations.

 

Praziquantel for Dogs and Cats Dosage

DOGS

Delivery

Parasites

Dose (against praziquantel-susceptible parasites)

Intramuscular

Echinococcus granulosus

5.7 mg/kg after confirmed diagn. Rep 24-48 h later

Intramuscular

Echinococcus multilocularis

5.7 mg/kg after confirmed diagn. Rep 24-48 h later

Oral

Tapeworms (general)

5 mg/kg

Oral

Diphyllobotrium spp

25 mg/kg/day x2 consec. days; or 35-40 mg/kg once

Oral

Dipylidium caninum

2.5-5 mg/kg

Oral

Echinococcus granulosus

5-10 mg/kg once; or 1 mg/kg/day x3 consec. days

Oral

Echinococcus multilocularis

5 mg/kg once; or 1 mg/kg/day x3 consec. days

Oral

Nanophyetus salmincola

4-12 mg/kg

Oral

Opisthorchis spp

100 mg/kg once; or 50 mg/kg twice at 24 h interval

Oral

Paragonimus spp

25 mg/kg/day x3 consec. days; or 25 mg/kg twice/day on 2 consec. days

Oral

Spirometra spp

7.5 mg/kg/day x2 consec. days; or 25 mg/kg once

Oral

Taenia hydatigena

2-5 mg/kg

Oral

Taenia pisiformis

1-5 mg/kg

Subcutaneous

Tapeworms (general)

5,7 mg/kg

Subcutaneous

Diphyllobotrium spp

25-40 mg/kg

Subcutaneous

Nanophyetus salmincola

4-12 mg/kg

Subcutaneous

Opisthorchis spp

100 mg/kg once; or 50 mg/kg twice with 24 h interval

Subcutaneous

Paragonimus kellicotti

25 mg/kg/day x3 consec. days

Subcutaneous

Spirometra spp

25 mg/kg/day x2 consec. days

Subcutaneous

Taenia pisiformis

1 mg/kg

CATS

Delivery

Parasites

Dose (against praziquantel-susceptible parasites)

Intramuscular

Echinococcus granulosus

5.7 mg/kg after confirmed diagn. Rep 24-48 h later

Intramuscular

Echinococcus multilocularis

5.7 mg/kg after confirmed diagn. Rep 24-48 h later

Oral

Tapeworms (general)

5 mg/kg

Oral

Diphyllobotrium erinacei

7.5- 15 mg/kg

Oral

Opisthorchis spp

100 mg/kg once; or 50 mg/kg twice with 24 h interval

Oral

Paragonimus kellicotti

25 mg/kg/day x3 consec. days

Oral

Platynosomum spp

20 mg/kg

Oral

Spirometra spp

20-30 mg/kg

Oral

Taenia pisiformis

1 mg/kg

Intramuscular

Opisthorchis spp

100 mg/kg once; or 50 mg/kg twice with 24 h interval

Intramuscular

Paragonimus kellicotti

25 mg/kg/day x3 consec. days

Intramuscular

Platynosomum concinnum

20 mg/kg

Topical (spot-on)

Tapeworms (general)

12-30 mg/kg

 

Missed Dose

To maintain the effectiveness of the medication, be careful not to miss a dose, and have the refill on the way before you run out.

In the case of a missed dose, keep up the regular schedule whenever possible. Skip the missed dose if it’s almost time for the next dose, then with the regular schedule. Doubling up is not advised.

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