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Ponazuril is an antiprotozoal drug used to treat protozoa diseases in dogs, cats, horses, and other animals. Some common protozoa diseases are EPM in horses, toxoplasmosis, and coccidiosis in dogs, cats, and other species. 

What is Ponazuril?

Ponazuril is used in veterinary medication. It is a metabolite of toltrazuril, the triazine class of antiprotozoals, which acts to inhibit enzyme systems in protozoa and/or decreasing pyrimidine synthesis. Ponazuril is coccidiocidal. 

What is Ponazuril Used for In Dogs?

Ponazuril is used for protozoa such as Isospora, Coccidia spp., Toxoplasma gondii, Sarcocystis neurona, and Eimeria spp. It is useful in treating Neospororsi or Toxoplasmosis, EPM, Coccidiosis, and Cryptosporidium spp. Ponazuril requires a prescription from your veterinarian. 

 Ponazuril Side Effects

Side effects of Ponazuril are: 

Common Side Effects 

  • Rashes
  • Hives
  • Blisters on nose and mouth

Less Common Side Effects

  • GI signs

If you notice any of these Ponazuril side effects in horses, cats, or dogs, contact your veterinarian right away. In the event of an allergic reaction, seek immediate medical attention for your animal.

Ponazuril Precautions

Soft feces may occur at high doses

Ponazuril may not be the best treatment for all veterinary patients.

        Who Should Not Use Ponazuril?

Ponazuril safety during pregnancy, in lactating mares, or breeding horses has not been evaluated.

Are There Any Drug Interactions With Ponazuril?

No drug interactions have been reported. 

Talk to your veterinarian before giving any prescription or over-the-counter medicines, including vitamins and minerals. 

Are There Any Risk Factors Associated With This Medication?

If any of the following serious side effects occur, stop giving Ponazuril and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue, or face; hives), scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, coma.

 Discontinue giving Ponazuril and contact your veterinarian if your pet develops; poor appetite, drowsiness, diarrhea, labored breathing, weakness, incoordination, fainting, accumulation of fluid in the lungs or abdomen, and cough. Other side effects may also occur. 

Talk to your veterinarian about any side effect that seems unusual or bothersome to the pet. 


Ponazuril capsules, powder, and paste should be stored at room temperature in a tightly sealed container and kept away from direct sunlight.

Liquid Ponazuril should also be stored at room temperature. Shake well before administering the dosage.

Medication should not be ingested by humans. In homes with children, a childproof container is recommended. If a human accidentally swallows this medication, call your doctor right away.


Give this medication exactly as directed by your veterinarian. If you do not understand these directions ask the veterinarian to explain them to you.

Be certain to complete the prescription unless specifically directed by your veterinarian. 

Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

Timeline Tips

  • Follow your veterinarian’s instructions as they may differ from these recommendations.
  • Finish the package and administer all doses. Don’t cease medication until your veterinarian has instructed.

Ponazuril for Dogs/Cats Dosage

Neosporosis or Toxoplasmosis (extra-label): 7.5 – 15 mg/kg PO once daily for 28 days

Coccidiosis (extra-label): 20 mg/kg PO once daily for 3 days. 

Ponazuril for Horses Dosage 

EPM labeled dose is 15 mg/kg PO as a loading dose on the first day, followed by 5 mg/kg PO once daily for 27days. 

Always follow your veterinarian’s directions strictly.

Missed Dose

To maintain the medication’s effectiveness, be careful not to miss a dose and have the refill on the way before you run out.

In the case of a missed dose, keep up the regular schedule whenever possible. Skip the missed dose if it’s almost time for the next dose, then with the regular schedule. 

Doubling up is not advised.

Can be given with or without food

Contact your veterinarian if signs of side effects develop.


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