Neo-Poly-Bac Ophthalmic Ointment

Neomycin/Polymyxin/Bacitracin is a non-steroid, triple-antibiotic ointment. It is used to treat bacterial eye infections of dogs, cats, small animals, or horses. Neo-poly-bac ophthalmic ointment can be applied to the eyelids, eyes, or tissue surrounding the eyes of the animal.

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Neo-Poly-Bac Ophthalmic Ointment Description

Therapeutic Class



Dogs, cats, and horses (or other animals per veterinary discretion).

May Be Prescribed by Vets for:

For the treatment or prevention of bacterial eye infections.

Dosage Forms: 

Ointment, 3.5 g per tube.

Active ingredients: Neomycin Sulfate 3.5 mg, Polymyxin B Sulfate 10,000 units, Bacitracin Zinc 400 units

Neo-Poly-Bac Side Effects

Most animals use this medication without any issues however, some side effects may occur. Be aware of these possible issues.

More Common Side Effects of Neo-Poly-Bac

  • Temporary stinging
  • Burning
  • Itching
  • Irritation
  • Redness
  • Eyelid itching swelling
  • Blurred vision
  • Sensitivity to light 
  • Thirstiness or urination when accidentally ingested

With mild side effects, you should continue to use the medication. Call the veterinarian to discuss any concerns you have about the effects on your animal.

Less Common Side Effects of Neo-Poly-Bac

  • Severe allergic reactions (such as anaphylaxis or conjunctival erythema).
  • Serious hypersensitivity
  • Reactions due to the corticosteroid ingredient: elevation of intraocular pressure (IOP), possible development of glaucoma, infrequent optic nerve damage, posterior subcapsular cataract formation, or delayed wound healing.
  • Secondary infections
  • Fungal and viral infections of the cornea after prolonged use.
  • Worsened infection from prolonged use.
  • Unusual behavior from the animal.
  • Local irritation on instillation.

Report signs of the above side effects to your veterinarian. You may need to stop using the medication if it causes itching, burning, or inflammation, but contact the vet’s office first. 

Contact the veterinarian immediately if your animal has any of the following issues:

  • Swelling in the lips, tongue, face, airways.
  • Difficulty breathing 
  • Profuse salivation
  • Vomiting  
  • Widespread hives
  • Itching or swelling
  • Breathing difficulty
  • Agitation

Warning: Cats may be severely allergic to neomycin or polymyxin B components of the ointment. Monitor felines for signs of such allergic reactions.

Neo-Poly-Bac Precautions

Be sure to inform your veterinarian of any medications your animal is currently taking (topical or otherwise) and provide a complete medical history (including all allergies). All of this information is needed to avoid adverse interactions or issues. Be sure to tell your veterinarian if a female patient is lactating or pregnant.

Take care of the applicator tip. It is intended to remain sterile. Keep it clean and don’t let it touch other surfaces, especially the flesh of an animal or human.

Neo-Poly-Bac is intended for bacterial infections and should not be used for viral or fungal eye infections.

Keep out of the reach of children and animals. Ingesting may be dangerous.

Do not give medication to other animals. It should only be used on the one it is prescribed for.

When an application is missed, do not make up for it with two doses. Instead, give it as soon as you remember. If it’s nearly time for the next dose, skip the missed dose entirely to get back on schedule.


How Do You Apply Neo Poly Bac to Dogs and Cats?

Crusted exudates, debris, or any other foreign particles should be removed from the eye before application. Using clean hands (with gloves, if available), tilt the animal’s head back and pull down the lower eyelid of the affected eye. 

Next, put a thin layer of Neo-poly-bac eye ointment on the lower eye (be careful not to let the applicator touch the eye). With the eye closed, carefully rub the eye for 1-2 minutes. Wash your hands after administering the application.

Repeat application to the affected eye(s) every 3 or 4 hours (or 3 or 4 times a day). The frequency of applications depends on the severity of the infection.

Use Neo poly bac ointment according to the vet-prescribed dosage instructions only. Follow any additional directions or administration guidance provided by your veterinarian. Contact the veterinarian for assistance when you have difficulty applying the medication.

Keep the applicator tip clean by avoiding contact (especially with skin or tissue).

Use medication for the number of days indicated by the prescribing vet, even when symptoms seem to dissipate sooner. Ceasing the medication too soon allows bacteria to grow, causing the infection to return.

Neo-Poly-Bac Ointment for Horses

Neo-Poly-Bac is typically a dog eye ointment, but this ointment is also an antibiotic solution for bacterial eye infections affecting horses. This is one of several possible medications your equine veterinarian may prescribe.


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