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Diethylstilbestrol  is a hormonal agent and a synthetic estrogen used to treat urinary incontinence and other diseases responsive to estrogen.

What is Diethylstilbestrol?

Diethylstilbestrol is a veterinary medication. It is a synthetic estrogen drug C18H20O2. Diethylstilbestrol is used to treat urinary incontinence in dogs. 

What is Diethylstilbestrol Used for In Dogs?

Diethylstilbestrol is used to treat urinary incontinence in dogs 

Diethylstilbestrol Side Effects in Dogs

Side effects of Diethylstilbestrol for dogs are uncommon. 

Serious Side Effects

  • Blood cell abnormalities
  • Weakness
  • Fever
  • Bleeding
  • Bloody diarrhea
  • Uterine infection
  • Vaginal discharge
  • Vomiting
  • Lack of appetite
  • Excessive water drinking
  • Mammary tumor development

Less Common Side Effects

  • Mild vaginal spotting 

If you notice any of these Diethylstilbestrol side effects in dogs contact your veterinarian right away. In the event of an allergic reaction, seek immediate medical attention for your animal.

Diethylstilbestrol Precautions

Diethylstilbestrol for dogs may not be the best treatment for all veterinary patients.

Who Should Not Use Diethylstilbestrol : 

Diethylstilbestrol should not be used in pets that are allergic to it, in females with estrogen-sensitive tumors, in pets with anemia or low white blood cell counts, or in animals that are intended to be used for food. It should be used with extreme caution in cats. Do not use in pets that are pregnant or lactating unless it is medically necessary.

Are There Any Drug Interactions With Diethylstilbestrol?

The following medications should be used with caution when given with diethylstilbestrol: azole antifungals, bupropion, cimetidine, corticosteroids, erythromycin, clarithromycin, phenobarbital, phenytoin, rifampin, tricyclic antidepressants, or warfarin. Be sure to tell your veterinarian about any medications.

Are There Any Risk Factors Associated With This Medication?

Other risk factors include signs of being in heat, including vaginal discharge or spotting, infection of the uterus in intact female dogs (pyometra), diarrhea, vomiting, lack of energy, increased water consumption, increased urination and feminization of male dogs. Side effects are more common in older animals.


Diethylstilbestrol tablets, capsules, chew treats and oral solution best stored in at room temperature in a dry place. All forms should be in a tightly sealed container and kept away from direct sunlight.

Liquid Diethylstilbestrol should also be stored at room temperature. Shake well before administering the dosage.

Medications should not be ingested by humans. In homes with children, a childproof container is recommended. If a human accidentally swallows this medication, call your doctor right away.


Dosing in dogs for hormone responsive incontinence is typically 0.1 to 1 mg orally once a day for three to five days, then the dosage is reduced to 1 mg orally once a week. Be certain to complete the prescription unless specifically directed by your veterinarian. 

Timeline Tips

  • Follow your veterinarian’s instructions as they may differ from these recommendations.
  • Finish the package and administer all doses. Don’t cease medication until your veterinarian has instructed.

Diethylstilbestrol Overdose 

Diethylstilbestrol overdose is uncommon but contact your veterinarian if you believe your pet is having side effects . Accidental ingestion should be treated immediately.


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